Noncationic Material Design for Nucleic Acid Delivery
نویسندگان
چکیده
منابع مشابه
Nucleic acid delivery: Where material sciences and bio-sciences meet
Advances in biotechnology have led to an accelerated discovery of macromolecular therapeutics such as peptides, proteins and polynucleotides. These macromolecules can be targeted against a variety of diseases, each requiring delivery to a well-defined compartment of the body. As such therapeutics are often prone to degradation before reaching their target site, or do not reach their target site...
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The delivery of nucleic acids to the pulmonary route appears to be promising due to non-invasiveness, large area of epithelial surface lining the lung, easy accessibility and ability to provide a platform for local delivery. The therapeutic role of nucleic acids in various diseases pertaining to the pulmonary route e.g. cystic fibrosis, α1-antitrypsin deficiency, asthma, chronic obstructive pul...
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The design of DNA and RNA sequences is critical for many endeavors, from DNA nanotechnology, to PCR-based applications, to DNA hybridization arrays. Results in the literature rely on a wide variety of design criteria adapted to the particular requirements of each application. Using an extensively studied thermodynamic model, we perform a detailed study of several criteria for designing sequence...
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6 Visual DSD code for PI controller implementations 13 6.1 Chemical Reaction Network implementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 6.2 4Domain DNA Strand Displacement implementation . . . . . . . . . . . . . . . . . . . . . . . . . . 16 6.2.1 Initial Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6.2.2 Reac...
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Gene therapy and immunotherapy are powerful techniques in the treatment of many life threatening diseases. The major challenge in these therapies is to seek a safe and efficient delivery carrier for gene and antigen materials. Carriers are designed to protect these molecules from degradation, improve their stability and facilitate the delivery of them to the site of action. This research study ...
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ژورنال
عنوان ژورنال: Advanced Therapeutics
سال: 2020
ISSN: 2366-3987,2366-3987
DOI: 10.1002/adtp.201900206